Journal: Current Research in Pharmacology and Drug Discovery

Article Title: A PAM of the α 1A -Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer’s disease mouse models without effects on blood pressure

doi: 10.1016/j.crphar.2023.100160

Figure Lengend Snippet: DMPK Parameters after oral administration of Cmpd-3.

Article Snippet: Intrinsic Clearance Mouse , Alliance Pharma , Mouse Liver Microsomes , 30.8 (ml/min/mg).

Techniques: Solubility, Clinical Proteomics, Binding Assay, Permeability, Inhibition

Journal: Frontiers in Pharmacology

Article Title: Urolithin A analog inhibits castration-resistant prostate cancer by targeting the androgen receptor and its variant, androgen receptor-variant 7

doi: 10.3389/fphar.2023.1137783

Figure Lengend Snippet: Microsomal and plasma stability ASR-600. Mouse microsomes were thawed and mixed with ASR-600 or control (Midazolam) (A) . ASR-600 and microsomes were incubated with or without cofactor (+NADPH) for indicated time points and plotted against area ratio. (B) . The area ratio was plotted against indicated time points for Midazolam (Table:1) Mouse microsomal stability. The elimination rate constant, half-life and intrinsic clearance of ASR-600 and control: Midazolam. Mouse plasma was mixed with ASR-600 or control (Eucatropine) (C) . ASR-600 and mouse plasma were incubated for indicated time points and analyzed with LC-MS/MS. (D) . The area ratio was plotted against indicated time points for Midazolam (Table:2) Plasma stability. Stability and rate constant of ASR-600 and control: Eucatropine.

Article Snippet: Pooled mouse liver microsomes were procured from BioIVT (USA).

Techniques: Clinical Proteomics, Control, Incubation, Liquid Chromatography with Mass Spectroscopy